Home - Links -Pharmaceuticals - Non-Steroidal Anti-Inflammatory Drugs (NSAIDS)
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How NSAIDs Work
'Nonsteroidal anti-inflammatory drugs work by interfering with the cyclooxygenase pathway'...
Selective COX-2 inhibitors: Are they safer NSAIDs?
'Only rofecoxib significantly reduced complicated ulcers'
Non-steroidal anti-inflammatory agents (NSAIDs)and Analgesics
'Nonsteroidal anti-inflammatory drugs (NSAIDs) are the drugs of choice for mild to moderate pain...'
Meloxicam , Drdoc on-line
'Meloxicam is variably claimed by Boehringer Ingelheim to be the First Generation of Selective COX 2- Cyclooxygenase Enzyme Inhibitors.
However it is NOT a specific COX 2 drug and inhibition of COX 1 occurs at its therapeutic concentration - causing the same overall profile of side effects as seen with the other conventional non steroidal anti-inflammatory drugs (NSAIDs)'.
Celecoxib, Virtual Drugstore
Celecoxib - Is it a Breakthrough Drug?, Therapeutics Initiative
Rofecoxib, Celecoxib -Safety of Arthritis Drugs in Question
'Vioxx, Celebrex May Up Risk of Kidney Failure, Heart Attack'
Questions Raised About Vioxx
'When compared to patients who took naproxen (Aleve), patients taking Vioxx were four times as likely to suffer from a heart attack'.
Vioxx - Physician Information Sheet, 4 Corners Pharmacy
'The efficacy of VIOXX is due to its specific inhibition of COX-2.'
Nimesulide, Pharmalicensing
'It is already known that COX-2 is only one of the mediators involved in inflammation and pain. Professor Alan Bennett, from the Guy's, King's and St. Thomas' Medical School in London (U.K.), showed several other mediators which are related to inflammation and pain: i.e. superoxide anions from neutrophils, histamine, cytokine TNFa and proteolytic enzymes. Nimesulide is the only NSAID able to affect all these substances. This results in significant anti-inflammatory and analgesic activities.'
Nimesulide (Mesulid), Schering-Plough International
'Nimesulide is the first NSAID that provides a complete control of the inflammatory process'.
Nimesulide® , International Antiaging Systems
'Nimesulide is an NSAID reported to be a selective inhibitor of cyclo-oxygenase-2 (COX-2)'.