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Biotin
'Researchers have speculated that biotin and alpha lipoic acid may compete with each other for absorption or uptake into cells; but little is known about the importance of these interactions in humans.'
Vitamin B12 - CATIE Supplement Sheet
'Depending on the way vitamin B12 levels are measured, studies suggest that between ten and 50 per cent of people living with HIV/AIDS (PHAs) are deficient in this nutrient.'
NEUROLOGICAL DISEASE A Potential Breakthrough
'Those suffering from peripheral neuropathies often take alpha lipoic acid. Based on our new understandings of peripheral neuropathy, we suggest that anyone using alpha lipoic acid also take at least 5 mg a day of sublingually administered methylcobalamin to ensure that alpha lipoic acid will be bioavailable to the peripheral nerves'.
METHYLCOBALAMIN B12 - The Methylated B12, Internetnutrition.com
'Methylcobalamin (methyl B12) is the neurologically active, most bioavailable and best utilized form of vitamin B12.'
Protection via Methylcobalamin
'Despite intensive searches for therapeutic agents, few substances have been convincingly shown to enhance nerve regeneration in patients with peripheral neuropathies. Recent biochemical evidence suggests that an ultra-high dose of methylcobalamin (methyl-B12) may up-regulate gene transcription and thereby protein synthesis.'
Methylcobalamin: monograph, Thorne
'Diabetic Neuropathy: Oral administration of methylcobalamin (500 mcg three times daily for four months) resulted in subjective improvement in burning sensations, numbness, loss of sensation, and muscle cramps.'
B-12 METHYLCOBALAMIN, George M Lucich
Methylcobalamin: A Potential Breakthrough in Neurological Disease
Few substances have been shown to regenerate nerves in humans with peripheral neuropathies. However, a study in the Journal of Neurological Science postulated that methylcobalamin could increase protein synthesis and help regenerate nerves. The scientists showed that very high doses of methylcobalamin produce nerve regeneration in laboratory rats.
Coping with Nerve Pain, B Vitamin Benefit